Relaxation PM
Also known as RP226
Quick facts
- Researched for
- Falling asleep more easily, winding down at night and staying asleep
- Route or form
- Injection
- Evidence so far
- Studies in people test GABA and melatonin on their own, not this blend.
- Not established
- No clinical trial has tested the finished blend itself.
- Commonly researched
- 0.25 to 0.5 mL, as needed on nights you are not sleeping well, not every night; step up by a quarter mL a week if neededPractitionerSee every range
- Where to get it
- At our partner, US Precision Peptides.Go to Next step
By the Learn Peptides editorial team · Updated · What changed: Forum reports replace a single account, and ingredient studies are now kept apart from the blend. · How We Research
What people are researching it for
People are researching Relaxation PM for falling asleep more easily, winding down at night, and staying asleep.
Reasons people look into Relaxation PM. An interest is not a promise that it works.
- Sleep
People mostly report falling asleep fast; staying asleep is hit or miss.
Community reports
People mainly report falling asleep faster after a strong rush of warmth or tingling. Reports on staying asleep are mixed.
Community reports
People take this ready-mixed shot at bedtime mostly to fall asleep faster. Forum reports often describe a rush of warmth or tingling within minutes, then strong sleepiness, but staying asleep is less consistent.
Sleep studies in people cover some of its parts, mostly melatonin.
Of its ingredients, melatonin has the most human sleep research. GABA's sleep evidence is very limited.
A ready-mixed of GABA, melatonin, L-arginine and L-glutamine, not a peptide. Of the four, melatonin has been studied the most for sleep.
What this is based on
- Human researchStudied in people for this or a related question.
- Community reportsWhat people describe noticing. Not proof of cause.
- Industry perspectiveCommentary from practitioners and the industry, based on experience. Not a study.
- Learn Peptides explanationOur own plain-English summary of the sources. It is not a source itself.
No clinical trial has tested the finished blend itself.
The finished itself has not been tested in a .
Safety notes
Tested in people. How many took part, for how long, and who they were still matter.
- You have trouble breathing or wheezing, or your face, lips, tongue or throat swell.
- You get hives away from the injection site, or feel severely dizzy or faint.
For these signs, call 911 or your local emergency number.
- Redness spreads, or heat, swelling or pain keeps growing where you injected.
- A lump keeps growing or does not go away, or you see pus or red streaks.
- You have a fever or chills, or feel sick all over.
- Too much melatonin can leave you with a headache and brain fog the next day. Industry perspective
- Products sold under this name can differ, so check the vial label.
- Any injected product needs to be sterile and free of endotoxin (bacterial residue that can cause fever). The strength on the label does not show that.
- Tingling, flushing, chest feelings and feeling short of breath come up often enough to take seriously.
- An allergic reaction can look like the rush at first. Trouble breathing, swelling, severe chest pain, fainting or symptoms that do not pass need emergency care.
- GABA and melatonin are calming, and their effects can add up with other sedating compounds or sleep medicine. Talk with a doctor before combining them. Taking several at once also makes it hard to tell what caused what.
Shows a practitioner's start-low range and an amount set by our editors.
Commonly researched ranges, and how they were measured.
Commonly researched range for Relaxation PM
0.25 to 0.5 mL
as needed on nights you are not sleeping well, not every night; step up by a quarter mL a week if needed · Injection
Practitioner
All 2 ranges in our record
Each one is labeled with where it comes from. They are different ways of using Relaxation PM, not steps to follow in order.
Start low and step up
Practitioner- Amount per dose
- 0.25 to 0.5 mL
- How often
- As needed on nights you are not sleeping well, not every night; step up by a quarter mL a week if needed. Right before bed, into the muscle.
- Typical schedule
- Not stated
- Route
- Injection
Full amount
Set by our editors- Amount per dose
- 1 mL
- How often
- Nightly, before sleep
- Typical schedule
- Not stated
- Route
- Injection
This figure is above the practitioner range above, which tops out at 0.5 mL and is not meant for every night. The practitioner took 1 mL once, slept deeply, and had a headache and grogginess until the next afternoon. Work up to it rather than starting here.
These ranges were last reviewed Sep 2026.
Not a peptide: GABA, melatonin and 2 amino acids, mixed and ready to use.
Relaxation PM is a ready-mixed , not a peptide. It holds GABA (a calming brain messenger), melatonin (the body's sleep-timing hormone) and 2 , L-arginine and L-glutamine. It is also sold as RP226 and comes ready to inject, with no mixing. Blends sold under the name can differ, so check the vial label.
Next step
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