SS-31
Also known as Elamipretide
Quick facts
- Researched for
- Cell energy, fatigue, endurance, recovery and longevity
- Route or form
- Injection
- Evidence so far
- FDA accelerated approval (2025) for Barth syndrome; heart trial fell short; wider claims lack trials.
- Not established
- Disease trials do not prove it helps healthy aging, wellness or performance.
- Commonly researched
- 1 to 2 mg, dailyPractitionerSee every range
- Where to get it
- At our partner, US Precision Peptides.Go to Next step
By the Learn Peptides editorial team · Updated · What changed: Its 2025 FDA approval is now named as accelerated, pending a confirming trial. An unconfirmed first-ever claim is gone. · How We Research
What people are researching it for
People are researching SS-31 for cell energy, fatigue, endurance, recovery, and longevity.
Mitochondrial support. Cellular energy. Whole-body impact.
- What is SS-31?
- a synthetic peptide composed of 4 amino acids
- Checklist: 4 amino acids
- Checklist: Also known as elamipretide, MTP-131 or Bendavia
- How does it work?
- Supports efficient energy production (ATP)
- Common research use cases
- Not written out in this text version.
- How it's used in research
- Route: Subcutaneous (most common)
- Route: Intravenous (used in clinical studies)
- Route: Other routes in research
- Common dosing: ~0.1 to 10 mg per day (varies by study)
- Common dosing: Clinical studies often use higher doses
- Common dosing: Duration varies from days to months
- Often combined with: Other mitochondrial support compounds
- Often combined with: Peptides (e.g., MOTS-C)
- Often combined with: Research protocols for specific goals
- There is no standardized dose or protocol. Research use should be thoughtful, tracked, and adjusted based on individual response.
- What users report
- Keep in mind: Responses vary widely
- Keep in mind: Some report fatigue or sedation
- Keep in mind: Injection site reactions common
- Keep in mind: More human studies are needed
- Key takeaway
- It's not a magic solution, but it shows real potential across multiple areas and is one of the most studied mitochondrial peptides.
- The bottom line
- SS-31 shows strong potential in research for energy, recovery, cognitive health, and healthy aging, but individual responses vary. Use only high-purity peptides, follow a research-focused approach, and set realistic expectations.
Reasons people look into SS-31. An interest is not a promise that it works.
- Injury & recovery
- Weight loss & metabolic
- Body composition & performance
- Longevity & energy
- Cognitive & mood
Most talk is about energy, fatigue, workouts and bouncing back, but few have tried it.
Community reports
Community discussion centers on energy, fatigue, exercise capacity, and recovery. Real-world experience is still limited compared with older, better-known compounds.
Community reports
People using SS-31 (elamipretide) mostly talk about it as an energy and fatigue fix, often taken before or alongside other -focused peptides. Reports on r/Peptides split between people who say it clearly helped and at least one long-time poster who calls it a waste of money.
It has been tested in people with some diseases tied to weak cell energy.
SS-31, also called elamipretide, has been tested in people with several diseases linked to poorly working , the parts of cells that make energy.
SS-31 got accelerated approval in 2025, and people outside its approved use take it for energy and fatigue.
What this is based on
- Human researchStudied in people for this or a related question.
- Cell / in vitroSeen in cells in a lab dish. An early signal, not proof it works in the body.
- Community reportsWhat people describe noticing. Not proof of cause.
- Industry perspectiveCommentary from practitioners and the industry, based on experience. Not a study.
- Learn Peptides explanationOur own plain-English summary of the sources. It is not a source itself.
Disease trials do not prove it helps healthy aging, wellness or performance.
Trials in specific diseases do not prove general healthy-aging, wellness, or performance benefits.
Safety notes
Tested in people. How many took part, for how long, and who they were still matter.
- You have trouble breathing or wheezing, or your face, lips, tongue or throat swell.
- You get hives away from the injection site, or feel severely dizzy or faint.
For these signs, call 911 or your local emergency number.
- Redness spreads, or heat, swelling or pain keeps growing where you injected.
- A lump keeps growing or does not go away, or you see pus or red streaks.
- You have a fever or chills, or feel sick all over.
- Avoid in pregnancy, active cancer, or other contraindicated conditions since it hasn't been studied there. Industry perspective
- Most common side effect is injection site reactions (redness, warmth, swelling, itching), more common at higher doses. Industry perspective
- In the practitioner's figures, 10 to 20% of people get headaches in the first 1 to 2 weeks. Water and electrolytes usually help. Industry perspective
- Some people get a temporary drop in energy in the first 7 to 10 days. Industry perspective
- Watch out for counterfeit product, or vials mislabeled as SS-31 that are actually cheaper MOTS-c. Industry perspective
Shows practitioner ranges, one trial's dose and what people report, each with its source.
Commonly researched ranges, and how they were measured.
Commonly researched range for SS-31
1 to 2 mg
daily · Injection
Practitioner
All 8 ranges in our record
Each one is labeled with where it comes from. They are different ways of using SS-31, not steps to follow in order.
Standard, general optimization (tier one)
Practitioner- Amount per dose
- 1 to 2 mg
- How often
- Daily
- Typical schedule
- Not stated
- Route
- Injection
Performance / subclinical decline (tier two)
Practitioner- Amount per dose
- 2 to 5 mg
- How often
- Daily
- Typical schedule
- Not stated
- Route
- Injection
Chronic illness / significant dysfunction (tier three)
Practitioner- Amount per dose
- 5 to 10 mg
- How often
- Daily
- Typical schedule
- Not stated
- Route
- Injection
Athletic performance / preconditioning before MOTS-c
Practitioner- Amount per dose
- 3 to 5 mg
- How often
- Daily
- Typical schedule
- Not stated
- Route
- Injection
Cognitive enhancement
Practitioner- Amount per dose
- 2 to 4 mg
- How often
- Daily
- Typical schedule
- Not stated
- Route
- Injection
Injury recovery (with BPC-157 + TB-500)
Practitioner- Amount per dose
- 2 to 4 mg
- How often
- Daily
- Typical schedule
- Not stated
- Route
- Injection
Severe migraine (anecdotal)
Practitioner- Amount per dose
- 5 to 10 mg
- How often
- Daily
- Typical schedule
- Results reported within 30 days
- Route
- Injection
MMPOWER-3 (elamipretide)
StudyTrial- Amount per dose
- 40 mg
- How often
- Once daily
- Typical schedule
- 24 weeks in the pivotal trial
- Route
- Injection
This is the amount a study used. It is not a dosing instruction for other products.
From our visual summary
Community reports
Community reports, from the Learn Peptides visual summary. These lines sit beside the ranges above and are not merged with them.
- Common dosing
- ~0.1 to 10 mg per day (varies by study)
- Clinical studies often use higher doses
- Duration varies from days to months
There is no standard dose. Track how you respond, and change one thing at a time.
These ranges were last reviewed Sep 2026.
Check your syringe math with your own numbers.
Also called elamipretide; FDA accelerated approval in 2025 for Barth syndrome, a rare muscle disease.
SS-31 is also known as elamipretide. In 2025, the gave it accelerated approval for a rare inherited muscle disease called Barth syndrome. That is an early approval, and a further trial must confirm that patients benefit. Instead of working through a like most peptides, it physically stabilizes the inner membrane structure of , the parts of a cell that make energy. It's given as an injection.
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