TB-500
Quick facts
- Researched for
- Tendon and ligament recovery, muscles, joints, inflammation and recovery after procedures
- Route or form
- Injection
- Evidence so far
- Mostly animal work and one human wound trial; cancer and long-term risks are not known.
- Not established
- Studies of the full protein do not prove the same for every product called TB-500.
- Commonly researched
- 500 to 1,000 mcg, once dailyPractitionerSee every range
- Where to get it
- Only inside blends, at our partner, US Precision Peptides.Go to Next step
By the Learn Peptides editorial team · Updated · What changed: The Achilles tendon result now names TB-500 itself, not its parent protein. · How We Research
What people are researching it for
People are researching TB-500 for tendon and ligament recovery, muscles, joints, inflammation, and recovery after procedures.
Repair. Recover. Move forward.
- What is TB-500?
- a synthetic peptide composed of 7 amino acids (Ac-LKKTETQ)
- Checklist: 7 amino acids
- How does it work?
- Not written out in this text version.
- Common research use cases
- Not written out in this text version.
- How it's used in research
- Route: Subcutaneous (most common)
- Route: Local (near injury)
- Route: Other routes (research only)
- Common dosing: 2.5 to 10 mg per week (varies by research goal)
- Common dosing: Often divided into 2 injections
- Common dosing: Duration typically 4 to 8+ weeks
- Common dosing: No standardized protocol
- Often combined with: BPC-157
- Often combined with: GHK-Cu
- Often combined with: Physical therapy
- Often combined with: Training modification
- Often combined with: Other research peptides
- There is no standardized dose or protocol. Research use should be thoughtful, tracked, and adjusted based on individual response.
- What users report
- Keep in mind: Results vary widely
- Keep in mind: Not everyone responds
- Keep in mind: Quality, dosing, and consistency may all influence outcomes
- Results often noticed after 3 to 6 weeks
- Key takeaway
- It's not a magic solution, and results vary. It's one of the most discussed peptides for a reason, but expectations should be realistic and research-based.
- The bottom line
- TB-500 shows strong potential in research, particularly for tendon, ligament, and soft tissue repair, but more high-quality human studies are needed. Use only high-purity peptides, follow a research-focused approach, and set realistic expectations.
Reasons people look into TB-500. An interest is not a promise that it works.
- Injury & recovery
- Immune support
- Skin, hair & tanning
Visual guides to blends that include TB-500; each blend is its own product.
Blends that include TB-500. A blend is its own product, with its own amounts.
Repair. Rejuvenate. Recover.
- What is the GLOW Stack?
- Vial illustrations: GHK-Cu 50 mg / BPC-157 10 mg / TB-500 10 mg, each labelled "Research Use Only"
- Checklist: Not an FDA-approved drug
- typically combines three research peptides
- How does it work?
- Sections: GHK-Cu; BPC-157; TB-500
- Common research use cases
- Not written out in this text version.
- How it's used in research
- Route: Subcutaneous (most common)
- Route: Local (near injury)
- Common blend: GHK-Cu: 50 mg
- Common blend: BPC-157: 10 mg
- Common blend: TB-500: 10 mg
- Common blend: (Variations are common)
- Typical duration: 4 to 8 weeks (common initial period)
- Typical duration: Some run longer based on goals
- There is no standardized dose or protocol. Research use should be thoughtful, tracked, and adjusted based on individual response.
- What users report
- Keep in mind: Results vary widely
- Keep in mind: Not everyone responds
- Keep in mind: May help with symptoms, but long-term effects are still unknown
- Key takeaway
- It's not a magic solution, but it has real potential and is one of the most discussed peptide combinations for a reason.
- The bottom line
- The GLOW Stack shows strong potential for skin, hair, collagen, and recovery support, but more high-quality human studies are needed. Use only high-purity peptides, follow a research-focused approach, and set realistic expectations.
Four peptides. Multiple pathways. A broader approach.
- What is the KLOW Stack?
- Checklist: Often supplied in an 80 mg blend (50:10:10:10)
- Vial illustrations: GHK-Cu 50 mg / BPC-157 10 mg / TB-500 10 mg / KPV 10 mg, each labelled "Research Use Only". The TB-500 in a KLOW vial is the TB-500 fragment.
- Checklist: Four complementary peptides
- How does it work?
- Sections: GHK-Cu; BPC-157; TB-500; KPV
- KPV sub-box: Anti-inflammatory (NF-κB pathway)
- Common research use cases
- Not written out in this text version.
- How it's used in research
- Route: Subcutaneous (and common)
- Route: Research protocols vary
- Route: Sometimes used individually or in combination
- Common blend: 80 mg total per vial
- Common blend: 50 mg GHK-Cu
- Common blend: 10 mg BPC-157
- Common blend: 10 mg TB-500
- Common blend: 10 mg KPV (ratios may vary by source)
- Typical research use: 1 to 2x per day
- Typical research use: Duration: 4 to 12 weeks (varies by goal)
- Typical research use: Often combined with proper nutrition, training, and recovery protocols
- There is no standardized dose or protocol. Research use should be thoughtful, tracked, and adjusted based on individual response.
- What users report
- Keep in mind: Results vary widely
- Keep in mind: Not everyone responds the same way
- Keep in mind: May help with symptoms, but long-term effects are still unknown
- Keep in mind: Use quality, independently tested products
- Key takeaway
- It's not a magic solution, but it may help you reach new goals by supporting multiple pathways in the body.
- The bottom line
- The KLOW Stack combines four peptides with complementary benefits. It may be a valuable research tool for people seeking multi-pathway support, but it's not risk-free. Use only high-purity peptides, follow a research-focused approach, and set realistic expectations.
BPC-157 + TB-500
- What is the Wolverine Stack?
- Checklist: Two complementary peptides
- How does it work?
- Sections: BPC-157; TB-500
- Common research use cases
- Not written out in this text version.
- How it's used in research
- Route: Subcutaneous (most common)
- Route: Local (near injury)
- Route: Oral (less common)
- Common dosing: BPC-157: 250 to 500 mcg per day
- Common dosing: TB-500: 1 to 2 mg per week
- Common dosing: Typical duration: 4 to 8 weeks (varies)
- Often combined with: Physical therapy
- Often combined with: Training modification
- Often combined with: Proper nutrition
- Often combined with: Other research peptides (e.g., GHK-Cu, KPV)
- There is no standardized dose or protocol. Research use should be thoughtful, tracked, and adjusted based on individual response.
- What users report
- Keep in mind: Results vary widely
- Keep in mind: Not everyone responds
- Keep in mind: May help with symptoms, but long-term tissue remodeling in humans is still unknown
- Key takeaway
- It's not a magic solution, but real-world reports suggest meaningful potential when used as part of a broader research and recovery strategy.
- The bottom line
- The Wolverine Stack (BPC-157 + TB-500) is one of the most discussed peptide combinations in the research community. It shows strong potential for tissue repair and recovery support, but more high-quality human studies are needed. Use only high-purity peptides, follow a research-focused approach, and set realistic expectations.
- Also printed on the image
- Vial illustrations: BPC-157 10 mg; TB-500 10 mg, each labelled "Research Use Only"
People say they pair it with other compounds, mostly for old tendon or joint injuries.
Community reports
Community research usually pairs TB-500 with other recovery compounds. Reports often focus on stubborn tendon, ligament, muscle, or joint problems rather than quick day-to-day effects.
Community reports
People mostly use TB-500 alongside BPC-157 for tendon, ligament, and post-surgery recovery, and many say pain and swelling eased up faster than expected. Almost every success story also involved other treatments at the same time, so it's hard to say TB-500 alone gets the credit.
Most studies test its parent protein in animals, with a little work on human wounds.
Most published research is on thymosin beta-4 in animals, with a smaller amount of human wound-healing research.
The broader partner to BPC-157, discussed for whole-body support across muscle and connective tissue.
What this is based on
- Animal researchUseful for understanding a research question, but not the same as evidence in people.
- Community reportsWhat people describe noticing. Not proof of cause.
- Industry perspectiveCommentary from practitioners and the industry, based on experience. Not a study.
- Learn Peptides explanationOur own plain-English summary of the sources. It is not a source itself.
Studies of the full protein do not prove the same for every product called TB-500.
Research on full-length thymosin beta-4 does not automatically prove the same effects for every product called TB-500 or TB-500 fragment.
Safety notes
Seen in animal studies. Results in animals often do not carry over to people.
- You have trouble breathing or wheezing, or your face, lips, tongue or throat swell.
- You get hives away from the injection site, or feel severely dizzy or faint.
For these signs, call 911 or your local emergency number.
- Redness spreads, or heat, swelling or pain keeps growing where you injected.
- A lump keeps growing or does not go away, or you see pus or red streaks.
- You have a fever or chills, or feel sick all over.
- Cancer, now or in the past. Studies link the protein it comes from to tumor spread and new blood-vessel growth. The cited commentary says to avoid it with active or recent cancer, and calls the risk unresolved: a theoretical concern, not a settled answer. One 2023 study even found thymosin beta-4 suppressed lung cancer in a different way. Talk to your oncologist first.
- Banned for tested/competitive athletes. Industry perspective
- Poor oral bioavailability: injection is the practical route. Industry perspective
- Injection site redness or itchiness can occur; Benadryl usually helps. Industry perspective
- Some people feel light-headed after injecting; eating beforehand can help. Industry perspective
- Long-term human safety data beyond a normal cycle length doesn't exist, which is part of why the cited commentary still recommends cycling even without evidence of desensitization.
Questions to bring to your doctor
Only for the conditions this page cautions about. Bring this page with you.
- I have or had cancer. Should I avoid TB-500, and what would you watch for?
Our view: best used with other recovery compounds; our partner sells it only in blends.
Product note, not a study
At Learn Peptides, we view TB-500 as best used alongside other recovery compounds. US Precision Peptides carries it only in .
Shows practitioner ranges by goal, kept apart from what people report.
Commonly researched ranges, and how they were measured.
Commonly researched range for TB-500
500 to 1,000 mcg
once daily · Injection
Practitioner
All 5 ranges in our record
Each one is labeled with where it comes from. They are different ways of using TB-500, not steps to follow in order.
Standard (general optimization)
Practitioner- Amount per dose
- 500 to 1,000 mcg
- How often
- Once daily
- Typical schedule
- 8 weeks on, 4-8 weeks off
- Route
- Injection
Active injury and recovery
Practitioner- Amount per dose
- 2,000 to 2,500 mcg
- How often
- Twice weekly, stepping down to once weekly for maintenance
- Typical schedule
- 8-12 weeks total: 2-2.5 mg twice weekly for 4-6 weeks, then 2 mg once weekly for 4-6 weeks
- Route
- Injection
Severe or complex injury
Practitioner- Amount per dose
- 2,000 to 5,000 mcg
- How often
- Twice weekly, tapering to once weekly
- Typical schedule
- 10-12 weeks total: 5 mg twice weekly for 2 weeks, then 2-2.5 mg twice weekly for 4 weeks, then 2 mg once weekly for 4-6 weeks
- Route
- Injection
Acute self-treatment (e.g. pulled muscle)
Practitioner- Amount per dose
- 2,500 to 5,000 mcg
- How often
- A couple of times a week until recovered
- Typical schedule
- Not stated
- Route
- Injection
Lung health
Practitioner- Amount per dose
- 2,000 to 5,000 mcg
- How often
- A few times per week
- Typical schedule
- Not stated
- Route
- Injection
From our visual summary
Community reports
Community reports, from the Learn Peptides visual summary. These lines sit beside the ranges above and are not merged with them.
- Common dosing
- 2.5 to 10 mg per week (varies by goal)
- Often divided into 2 injections
- Duration typically 4 to 8+ weeks
- No standard schedule
There is no standard dose. Track how you respond, and change one thing at a time.
These ranges were last reviewed Sep 2026.
Check your syringe math with your own numbers.
A lab-made piece of a natural body protein, most often paired with BPC-157.
TB-500 is a synthetic fragment of Thymosin Beta-4, a protein the body already makes. Where BPC-157 tends to work locally, TB-500 is discussed as acting more systemically, for the kind of chronic tightness that slows recovery down. Part of how it is proposed to work is by encouraging new blood vessel growth, which is also why it is the compound people with a history of cancer most often choose to avoid. It's almost never discussed on its own; it comes up as BPC-157's usual pairing.
People often pair these two for injury recovery. They are different compounds, so it helps to compare what people report, what studies show and the cautions for each.
Next step
Products that contain TB-500
Available blend options are listed below.
- Shop for Wolverine 60 mg (link to our partner, US Precision Peptides, opens in a new tab)
US Precision Peptides
Wolverine 60 mg
BPC-157 30 mg + TB-500 fragment 30 mg
The larger size of this blend, for the 4 to 8 week runs that community reports describe. This is about package size, not a personal dose. This is a blend. Read about Wolverine
- Shop for Wolverine 20 mg (link to our partner, US Precision Peptides, opens in a new tab)
US Precision Peptides
Wolverine 20 mg
BPC-157 10 mg + TB-500 fragment 10 mg
A smaller package of the same blend. This is a blend. Read about Wolverine
- Shop for GLOW 70 mg (link to our partner, US Precision Peptides, opens in a new tab)
US Precision Peptides
GLOW 70 mg
GHK-Cu 50 mg + BPC-157 10 mg + TB-500 fragment 10 mg
A related blend with other ingredients. This is a blend. Read about GLOW
- See KLOW at US Precision Peptides (link to our partner, US Precision Peptides, opens in a new tab)
US Precision Peptides
KLOW 80 mg
GHK-Cu 50 mg + BPC-157 10 mg + TB-500 fragment 10 mg + KPV 10 mg
A related blend with other ingredients. This is a blend. Read about KLOW
A blend vial holds its ingredients in a fixed ratio, so TB-500 cannot be measured on its own.
About product links
Purchases at US Precision Peptides help keep Learn Peptides free.